About

Bio

I was born and raised in Thessaloniki, Greece. I graduated from Anatolia College in 1993. I received my Diploma in Chemical Engineering from the Aristotle University of Thessaloniki, my MSc in Process Systems Engineering from Imperial College and my PhD on Optimisation of Biochemical Systems from University College London (UCL). For almost 5 years, I worked for theManchester Centre for Integrative Systems Biology (MCISB) at the University of Manchester. I am now a researcher at the Luxembourg Centre for Systems Biomedicine (LCSB), currently on a long term visit to the Institute for Systems Biology (ISB) in Seattle, Washington.

Research Interests
Systems Biology
My research focuses on the development of mathematical models for the analysis of biological networks. These range from fully parameterised, kinetic models of pathways to genome-scale models of either kinetic or purely stoichiometric nature. The analysis and control of metabolic flux is also among my main interests. The techniques I use for the modelling of these systems vary from kinetic, ODE-based modelling, to stoichiometric, optimization-based approaches (e.g. Flux Balance Analysis). At the same time, I develop novel, hybrid approaches for the characterization of metabolic behaviour.

Metabolism
One of my main interests is the mathematical modelling of the metabolism of baker’s yeast and homo sapiens. I have participated in the development of new technologies in Systems Biology, a new conceptual view on biological research that uses complex computational and mathematical analysis to advance traditional methods. I develop necessary methods and techniques for the analysis of biological networks using yeast (Saccharomyces cerevisiae) as a model organism, but I am also very interested in applying these methodologies to mammalian and human systems.

Mathematical Programming and Integer Optimisation
The object of this research is the application of mathematical programming and optimisation methodologies to problems of biological and biochemical nature. Main research areas that I have examined include protein folding, metabolic pathway analysis, p53 apoptotic control network and synthesis of peptide purification tags for downstream protein processing.